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Human SSTR5/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1337
Background
Somatostatin (SST) is a multifunctional peptide with two biologically active forms, SST-14 and SST-28, which are synthesized in neurons throughout the brain as well as in peripheral tissues such as the pancreas and the gut. SST exerts a diverse array of effects that include inhibition of endocrine secretion, modulation of neurotransmission, and regulation of cell proliferation by stimulating a family of five G-protein-coupled receptors. Somatostatin receptor SST5 is an inhibitory G protein-coupled receptor that exerts a strong cytostatic effect on various cell types. In mice, SST5 mediates somatostatin inhibition of pancreatic insulin secretion and contributes to the regulation of glucose homeostasis and insulin sensitivity. In addition, deficiency of SST5 leads to subtype-selective sexually dimorphic changes in the expression of both brain and pancreatic somatostatins.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
SSTR5
Synonyms
SSTR5; somatostatin receptor 5; somatostatin receptor type 5; somatostatin receptor subtype 5; SS-5-R;
Gene ID
MIM
UniProt ID
P35346
Chromosome Location
16p13.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity; somatostatin receptor activity;

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