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Human S1PR2/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0687
Background
Sphingosine 1-phosphate (S1P) is a bioactive lipid that binds to and activates a family of GPCRs, S1P1-5 (also known as EDG receptors). Interactions between S1P and its receptors mediate cytoskeletal rearrangement and cell migration, with functional consequences in angiogenesis, lymphocyte trafficking, and smooth muscle development. S1P1 (Edg-1) signals exclusively through Gi, whereas S1P2 (Edg-5) and S1P3 (Edg-3) activate Gi, Gq and G12/13. Although S1P1 and S1P3 promote cell migration, S1P2 inhibits cell migration in several cell types; these opposing functions appear to result from differences in the ability of each receptor to activate Gi. Studies with knockout mice indicate that S1P2 and S1P3 have redundant functions in maintaining vascular integrity during embryonic development.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
S1PR2
Synonyms
EDG5; H218; LPB2; S1P2; AGR16; EDG-5; Gpcr13; sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P receptor EDG5; S1P receptor Edg-5; sphingosine 1-phosphate receptor Edg-5; endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
Gene ID
MIM
UniProt ID
O95136
Chromosome Location
19p13.2
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (i) signalling events; GPCR downstream signaling; GPCR ligand binding; Lysosphingolipid and LPA receptors; Neuroactive ligand-receptor interaction; S1P2 pathway;
Function
G-protein coupled receptor activity; Lipid binding; sphingosine-1-phosphate receptor activity

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