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Human RXR beta(LBD)-GAL4(DBD) Stable Cell Line-HEK 293T(UAS-bla)

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Cat.No.
CSC-RN0032
Background
The Retinoid X receptor-beta (RXR beta) is a nuclear hormone receptor and can function as a ligand inducible transcription factor capable of acting as a co-repressor and/or co-activator for gene expression. Nuclear receptors contain a series of conserved domains or regions. These domains/regions include a variable NH2-domain (A/B region), a conserved DNA-binding domain (DBD or region C), a linker region (region D), a ligand binding domain (LBD or region E), and in some receptors a variable COOH-terminal (region F). RXR beta belongs to the family of retinoid x receptors, one of two retinoic receptor families (retinoic acid receptors and retinoid x receptors). RXR beta is one of three members of the RXR family which consists of RXR alpha, RXR beta, and RXR gamma. The A/B and D regions of RXR beta are involved in dictating the cell dependent transcriptional response. RXR receptors are able to form both homo- and heterodimers. RXR receptors have been reported to form heterodimers with TRs (thyroid hormone receptors), RXRs retinoic acid receptors), VDR (vitamin D receptor), PPARs (peroxisome proliferator activated receptors), LXRs (liver x receptors), and FXR (farnesoid x receptor). These heterodimers can be classified as permissive and nonpermissive heterodimers. Addition of an RXR agonist, such as 9-cis-retinoic acid, can result in transcriptional activity of permissive heterodimers while activation of nonpermissive heterodimers occurs independent of the RXR agonist. RXR agonist LG100268 activates the transcriptional response RXR:PPARγ and RXR:LXR heterodimers alone and synergistically with PPARγ and LXR agonists, but does not activate RXR:RXR and RXR:TR heterodimers whose activity is dependent upon RXR and TR agonists. RXR beta is widely expressed in almost every tissue. The generation of RXR beta null mice resulted in approximately 50% of the mice to die before birth and those that survived appear normal, except for male sterility.
The endogenous ligands for RXR beta include 9-cis-retinoic acid, phytanic acid, and docosahexaenoic acid. Synthetic agonists for RXR beta have been termed rexinoids and includes LG100268.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK 293T
Ship
Dry ice
Gene Information
Official Symbol
RXRB
Synonyms
RXRB; retinoid X receptor, beta; retinoic acid receptor RXR-beta; H 2RIIBP; NR2B2; nuclear receptor subfamily 2 group B member 2; RCoR 1; retinoid X nuclear receptor beta; MHC class I promoter binding protein; DAUDI6; RCoR-1; H-2RIIBP; MGC1831;
Gene ID
MIM
UniProt ID
P28702
Chromosome Location
6p21.3
Pathway
Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Non-small cell lung cancer, organism-specific biosystem; Non-small cell lung cancer, conserved biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem;
Function
9-cis retinoic acid receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; protein binding; protein heterodimerization activity; receptor activity; retinoic acid receptor binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid binding; steroid hormone receptor activity; thyroid hormone receptor binding; thyroid hormone receptor coactivator activity; transcription coactivator activity; transcription regulatory region DNA binding; vitamin D receptor binding; zinc ion binding;

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