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Human RXR alpha(LBD)-GAL4(DBD) Stable Cell Line-HEK 293T(UAS-bla)

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Cat.No.
CSC-RN0030
Background
The Retinoid X receptor-alpha (RXR alpha) is a nuclear hormone receptor and can function as a ligand inducible transcription factor capable of acting as a co-repressor and/or coactivator for gene expression. Nuclear receptors contain a series of conserved domains or regions. These domains/regions include a variable NH2-domain (A/B region), a conserved DNA-binding domain (DBD or region C), a linker region (region D), a ligand binding domain (LBD or region E), and in some receptors a variable COOH-terminal (region F). RXR alpha belongs to the family of retinoid X receptors, one of two retinoic receptor families (retinoic acid receptors and retinoid X receptors). RXR alpha is one of three members of the RXR family which consists of RXR alpha, RXR beta, and RXR gamma. The A/B and D regions of RXR alpha are involved in dictating the cell dependent transcriptional response. RXR receptors are able to form both homo- and heterodimers. RXR receptors have been reported to form heterodimers with TRs (thyroid hormone receptors), RARs retinoic acid receptors), VDR (vitamin D receptor), PPARs (peroxisome proliferators activated receptor), LXR (liver X receptor), and FXR (farnesoid X receptor). These heterodimers can be classified as permissive and nonpermissive heterodimers. Addition of a RXR agonist, such as 9-cis-retinoic acid, can result in transcriptional activity of permissive heterodimers while activation of nonpermissive heterodimers occurs independent of the RXR agonist. RXR alpha agonist LG100268 activates the transcriptional response RXR:PPAR gamma and
RXR:LXR heterodimers alone and synergistically with PPAR gamma and LXR agonists, but does not activate RXR:RAR and RXR:TR heterodimers whose activity is dependent upon RAR and TR agonists. RXR alpha is expressed in the liver, spleen, placenta, epidermis, central nervous system, and is implicated in embryo development and differentiation. With its ability to form heterodimers with other nuclear receptors, RXR alpha has potential roles in lipid metabolism, skin alopecia, dermal cysts, cardiac development, insulin sensitization, and gene regulation. RXR activation has been shown in the spinal cord, brain, and epithelia of transgenic Xenopus laevis embryos. The development of a loss of function mutation of RXR alpha in a mouse germ line resulted in embryonic lethality due to defects in the ventricular walls of the heart.The endogenous ligands for RXR alpha include 9-cis-retinoic acid, phytanic acid, and docosahexaenoic acid. Synthetic agonists for RXR alpha have been termed rexinoids and include LG100268.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK 293T
Ship
Dry ice
Gene Information
Official Symbol
RXRA
Synonyms
RXRA; retinoid X receptor, alpha; retinoic acid receptor RXR-alpha; NR2B1; nuclear receptor subfamily 2 group B member 1; retinoid X nuclear receptor alpha; FLJ00280; FLJ00318; FLJ16020; FLJ16733; MGC102720;
Gene ID
MIM
UniProt ID
P19793
Chromosome Location
9q34
Pathway
Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Bile secretion, organism-specific biosystem; Bile secretion, conserved biosystem; Circadian Clock, organism-specific biosystem;
Function
9-cis retinoic acid receptor activity; DNA binding; double-stranded DNA binding; enzyme binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; protein binding; protein heterodimerization activity; receptor activity; retinoic acid receptor activity; retinoic acid-responsive element binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; contributes_to sequence-specific DNA binding transcription factor activity; steroid binding; steroid hormone receptor activity; transcription coactivator activity; contributes_to transcription regulatory region DNA binding; vitamin D receptor binding; contributes_to vitamin D response element binding; zinc ion binding;
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Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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