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Human RXFP4 Stable Cell Line-CHO Galpha16

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Cat.No.
CSC-RG0929
Background
The RXFP4 receptor belongs to the Relaxin Family Peptide Receptors family. It was originally cloned as orphan receptor GPR100 and GPR142 but subsequently has been shown to be the physiological target for INSL3 (insulin-like peptide 3); it also responds to relaxin-3 at high affinity. Human RXFP4 is expressed in heart, skeletal muscle, kidney, liver and placenta and has been shown to be Gi-coupled. This cell line couples via Ga16 to the calcium pathway. Although to our knowledge RXFP4 has yet to be used as a drug discovery target, this cell line will provide utility for counter-screening compounds targeted to other members of this family that may have therapeutic utility for a wide range of diseases including cardiac and renal failure (RXFP1), asthma (RXFP1), scleroderma (RXFP1), infertility and contraception (RXFP2), anti-anxiety and anti-obesity (RXFP3).
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Stability
At least 6 passages
Ship
Dry ice
Gene Information
Official Symbol
RXFP4
Synonyms
RXFP4; relaxin/insulin-like family peptide receptor 4; G protein coupled receptor 100 , GPR100, relaxin 3 receptor 2 , relaxin family peptide receptor 4 , RLN3R2; relaxin-3 receptor 2; GPCR142; RXFPR4; RLN3 receptor 2; relaxin 3 receptor 2; G protein-coupled receptor 100; G-protein coupled receptor 100; relaxin family peptide receptor 4; G-protein coupled receptor GPCR142; insulin-like peptide INSL5 receptor; GPR100; RLN3R2; MGC126556; MGC126558;
Gene ID
MIM
UniProt ID
Q8TDU9
Chromosome Location
1q22
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Peptide ligand-binding receptors, organism-specific biosystem; Relaxin receptors, organism-specific biosystem; Signal Transduction, organism-specific biosystem;
Function
G-protein coupled receptor activity; angiotensin type II receptor activity; receptor activity; signal transducer activity;

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