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Human RAR alpha(LBD)-GAL4(DBD) Stable Cell Line-HEK 293T(UAS-bla)

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Cat.No.
CSC-RN0022
Background
The retinoic acid receptor alpha (RAR alpha) is a nuclear hormone receptor and can function as a ligand inducible transcription factor capable of acting as a co-repressor and/or co-activator for gene expression. Nuclear receptors contain a series of conserved domains or regions. These domains/regions include a variable NH2-domain (A/B region), a conserved DNA-binding domain (DBD or region C), a linker region (region D), a ligand binding domain (LBD or region E), and in some receptors a variable COOH-terminal (region F). The RAR DNA binding domain recognizes and interacts with the retinoic acid receptor response elements (RAREs). RAR binds as a heterodimer with RXR. The RAR/RXR heterodimer is associated with corepressor proteins at the RAREs in the absence of ligand. Upon binding of ligand, RAR undergoes a conformational change, releasing corepressor proteins and allowing for the interaction with coactivator proteins that enhance RARE driven gene transcription. RAR alpha is a member of the Retinoic Acid Receptor family. Retinoids, vitamin A and its natural and synthetic analogues, are a very important group of hormones that regulate a wide variety of biological functions including embryogenesis, cell growth, and cell differentiation. Cotransfection experiments showed that RARs are activated by either all-trans- or 9-cis-retinoic acid at a ligand concentration of 5 X 10^-8 mmol/L.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK 293T
Ship
Dry ice
Gene Information
Official Symbol
RARA
Synonyms
RARA; retinoic acid receptor, alpha; retinoic acid receptor alpha; NR1B1; RAR; RAR-alpha; retinoic acid receptor, alpha polypeptide; nuclear receptor subfamily 1 group B member 1; retinoic acid nuclear receptor alpha variant 1; retinoic acid nuclear receptor alpha variant 2; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form;
Gene ID
MIM
UniProt ID
P10276
Chromosome Location
17q21.1
Pathway
Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adipogenesis, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; IL-3 Signaling Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem;
Function
chromatin DNA binding; enzyme binding; metal ion binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein kinase A binding; protein kinase B binding; receptor activity; receptor binding; retinoic acid binding; retinoic acid receptor activity; retinoic acid-responsive element binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription coactivator activity; transcription coactivator activity; transcription corepressor activity; transcription factor binding; zinc ion binding;
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AD13444Z
>1x 10^9 vp/ml
1 x 0.2 ml
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