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Human PTH1R/beta-Arrestin Stable Cell Line-CHO

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Cat.No.
CSC-RG1591
Background
Parathyroid hormone (PTH) plays a critical role in mineral ion homeostasis, particularly in bone and kidney. A related peptide, parathyroid hormone-related peptide (PTHrP), plays an important role in skeletal development. Both peptides exert their biological actions by binding to a class B GPCR, PTH1, that signals primarily by activation of adenylate cyclase. Mutations in PTH1 have been identified as the cause of Jansen"s metaphyseal chondrodysplasia, Blomstrand"s chondrodysplasia, and enchondromatosis. Intermittent treatment with PTH has important clinical utility in building bone mass in patients with osteoporosis.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
PTH1R
Synonyms
PTH1R; parathyroid hormone 1 receptor; parathyroid hormone receptor 1 , PTHR, PTHR1; parathyroid hormone/parathyroid hormone-related peptide receptor; PTH1 receptor; PTH/PTHr receptor; PTH/PTHrP type I receptor; parathyroid hormone receptor 1; seven transmembrane helix receptor; parathyroid hormone/parathyroid hormone-related protein receptor; PFE; PTHR; PTHR1; MGC138426; MGC138452;
Gene ID
MIM
UniProt ID
Q03431
Chromosome Location
3p22-p21.1
Pathway
Class B/2 (Secretin family receptors), organism-specific biosystem; Endochondral Ossification, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, organism-specific biosystem; Endocrine and other factor-regulated calcium reabsorption, conserved biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
parathyroid hormone receptor activity; peptide hormone binding; protein self-association; receptor activity; signal transducer activity;

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