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Human PTGIR/beta-Arrestin Stable Cell Line-HEK293

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Cat.No.
CSC-RG1589
Background
The human prostaglandin I2 receptor IP1 (or PTGIR) mediates the actions of prostaglandin I2 (PGI2 or prostacyclin), which is a labile metabolite of arachidonic acid produced in concert with the bis-enoic prostaglandins via the cyclooxygenase pathway. PGI2 plays a major physiologic role as a strong mediator of vasodilation and inhibitor or platelet activation, and is an antithrombotic agent in vivo and mediates inflammation and pain. PGI2 derived from COX2 plays a critical role in regulating the release of rennin and consequently in renovascular hypertension.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
PTGIR
Synonyms
PTGIR; prostaglandin I2 (prostacyclin) receptor (IP); prostacyclin receptor; IP; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor; PRIPR; MGC102830;
Gene ID
MIM
UniProt ID
P43119
Chromosome Location
19q13.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function
G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;

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