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Human PTGIR/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0744
Background
Prostacyclin (PGI2) is released by vascular endothelial cells and serves as a potent vasodilator, inhibitor of platelet aggregation, and moderator of vascular smooth muscle cell proliferation-migration-differentiation. The function of protacyclin is mediated via a seven transmembrane GPCR, IP1, which is known to couple to Gs and Gq signaling pathways. Mice lacking the IP1 receptor have shown increased susceptibility to thrombosis, enhanced injury-induced vascular proliferation and platelet activation), as well as reperfusion injury. The recent world-wide withdrawal of selective COX-2 inhibitors, rofecoxib(Vioxx) and valdecoxib(Bextra), is also due to their discriminating suppression of COX-2-derived prostacyclin and IP1-mediated cardioprotective effects, leading to increased risk of cardiovascular events.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
PTGIR
Synonyms
PTGIR; prostaglandin I2 (prostacyclin) receptor (IP); prostacyclin receptor; IP; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor; PRIPR; MGC102830;
Gene ID
MIM
UniProt ID
P43119
Chromosome Location
19q13.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function
G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;
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Cat#
Product Name
Titer
Product Size
Species
Price
AD13143Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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