Tel: 1-631-626-9181 (USA)   44-207-097-1828 (Europe)

Human PTGIR/Galpha15 Stable Cell Line-Chem-1

See other products for PTGIR
Cat.No.
CSC-RG0744
Background
Prostacyclin (PGI2) is released by vascular endothelial cells and serves as a potent vasodilator, inhibitor of platelet aggregation, and moderator of vascular smooth muscle cell proliferation-migration-differentiation. The function of protacyclin is mediated via a seven transmembrane GPCR, IP1, which is known to couple to Gs and Gq signaling pathways. Mice lacking the IP1 receptor have shown increased susceptibility to thrombosis, enhanced injury-induced vascular proliferation and platelet activation), as well as reperfusion injury. The recent world-wide withdrawal of selective COX-2 inhibitors, rofecoxib(Vioxx) and valdecoxib(Bextra), is also due to their discriminating suppression of COX-2-derived prostacyclin and IP1-mediated cardioprotective effects, leading to increased risk of cardiovascular events.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
PTGIR
Synonyms
PTGIR; prostaglandin I2 (prostacyclin) receptor (IP); prostacyclin receptor; IP; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor; PRIPR; MGC102830;
Gene ID
MIM
UniProt ID
P43119
Chromosome Location
19q13.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function
G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;

Quick Inquiry

Please input "biogene" as verification code.

PTGIR Related Products

Transfected Stable Cell Lines

By Gene symbol(9)
+Expand
By Species(9)
+Expand

Premade Virus Particles

By Gene symbol(1)
+Expand
By Species(1)
+Expand

Clones

By Gene symbol(11)
+Expand
By Species(11)
+Expand
By MicroRNA Accession No.(3)
+Expand

Contact Us

USA

Europe

CBpromise   

Our promise to you:
Guaranteed product quality, expert customer support.

24x7 CUSTOMER SERVICE
CONTACT US TO ORDER