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Human PTGFR/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0743
Background
Prostanoids are a series of arachidonic acid metabolites produced by the action of cyclooxygenase and subsequently by isomerases and synthases. Cells rapidly secrete prostanoids after synthesis, whereupon the prostanoids bind to a family of 8 GPCRs to exert their biological effects. The prostaglandin PGF2alpha binds specifically to the FP receptor, which couples to Gq/11 to mobilize intracellular calcium. Binding of PGF2alpha to FP receptors in the corpus luteum is required for luteolysis and subsequent parturition in mice. PGF2alpha also decreases intraocular pressure by an FP-dependent mechanism, and an PGF2--analog--latanoprost, is used clinically in the treatment of glaucoma. FP also contributes to tachycardia induced by inflammatory stimuli.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
PTGFR
Synonyms
PTGFR; FP; prostaglandin F receptor (FP); RP5-944H6.1; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostaglandin F2 alpha receptor; prostaglandin F2-alpha receptor; prostaglandin receptor (2-alpha); prostanoid FP receptor
Gene ID
MIM
UniProt ID
P43088
Chromosome Location
1p31.1
Pathway
Calcium signaling pathway; Class A/1 (Rhodopsin-like receptors); Eicosanoid ligand-binding receptors; GPCR downstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like; Gastrin-CREB signalling pathway via PKC and MAPK
Function
prostaglandin F receptor activity

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