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Human PTGER4-FLAG Stable Cell Line-HEK293T

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Cat.No.
CSC-RG0366
Background
The human prostaglandin E2 (PGE2) receptor EP4 (or PTGER4) is abundantly expressed. Activation of EP4 receptor induces osteoblasts and thereby stimulates de novo bone formation. Results from targeted deletion of the EP4 receptor also suggest that the EP4 subtype of the PGE2 receptor is involved in lipopolysaccharide-induced bone resorption. Modulating EP4 action may thus prove to be clinically useful for the treatment of bacterially induced bone loss, such as in periodontitis and osteomyelitis. EP4 also plays a role in the anti-inflammatory action of PGE2 in human macrophage.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T
Ship
Dry ice
Gene Information
Official Symbol
PTGER4
Synonyms
PTGER4; prostaglandin E receptor 4 (subtype EP4); prostaglandin E2 receptor EP4 subtype; EP4; prostanoid EP4 receptor; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype; EP4R; MGC126583;
Gene ID
MIM
UniProt ID
P35408
Chromosome Location
5p13.1
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; prostaglandin E receptor activity; protein binding; receptor activity; signal transducer activity;

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