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Human PTGER3/Gi/Go Stable Cell Line-CHO

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Cat.No.
CSC-RG0577
Background
Prostaglandin E2 (PGE2) is involved in a number of physiologic and pathophysiologic events in many tissues of the body. The biologic effects of PGE2 are mediated through interaction with specific membrane-bound G protein-coupled prostanoid EP receptors. EP3 receptor (or PTGER3) is expressed as multiple transcripts through alternative splicing, with each transcript showing a different tissue-specific distribution. PGE2 may mediate fever generation in response to both endogenous and exogenous pyrogens by acting at the EP3 receptor. EP3-mediated neuronal pathways converge at corticotropin-releasing hormone containing neurons in the paraventricular nucleus of the hypothalamus to induce HPA axis activation during sickness. At cellular level, EP3 has been shown to couple to both Gs and Gi/o types of the heterotrimeric G proteins to stimulate or inhibit intracellular cAMP synthesis. This cell line does not respond to pertussis toxin (PTX) treatment, indicating its coupling to Gi/o proteins is insignificant.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
PTGER3
Synonyms
PTGER3; prostaglandin E receptor 3 (subtype EP3); prostaglandin E2 receptor EP3 subtype; EP3; prostanoid EP3 receptor; PGE receptor, EP3 subtype; PGE2 receptor EP3 subtype; prostaglandin receptor (PGE-2); prostaglandin E receotor EP3 subtype 3 isoform; EP3e; EP3-I; EP3-II; EP3-IV; PGE2-R; EP3-III; MGC27302; MGC141828; MGC141829;
Gene ID
MIM
UniProt ID
P43115
Chromosome Location
1p31.2
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled receptor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; prostaglandin E receptor activity; prostaglandin E receptor activity; receptor activity; signal transducer activity;

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