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Human PTGER2/Clytin Stable Cell Line-HEK293

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Cat.No.
CSC-RG0738
Background
Prostanoids bind to a family of 8 GPCRs to exert their biological effects. The prostanoid PGE2 causes pain, vasodilation, immunosuppression of T cells, bone resorption and promotion of carcinogenesis. Four related GPCRs, EP1, EP2, EP3 and EP4, each bind PGE2, but the different G protein coupling of each receptor leads to distinct biological effects. EP2 couples primarily to Gs to increase intracellular cAMP levels. Mice deficient in EP2 receptor showed impaired ovulation and fertilization in addition to salt-sensitive hypertension. It has been shown that EP2 receptors are also involved in cancer-associated immunodeficiency. Thus, genetic knockout of the EP2 receptor reduced tumor growth and prolonged survival in mice that had undergone isograft injection of MC26 or Lewis lung carcinoma cells.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
PTGER2
Synonyms
PTGER2; prostaglandin E receptor 2 (subtype EP2), 53kDa; prostaglandin E receptor 2 (subtype EP2), 53kD; prostaglandin E2 receptor EP2 subtype; EP2; prostanoid EP2 receptor; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype;
Gene ID
MIM
UniProt ID
P43116
Chromosome Location
14q22
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; prostaglandin E receptor activity; receptor activity; signal transducer activity;

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