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Human PTGER1-FLAG Stable Cell Line-HEK293T

See other products for PTGER1
Cat.No.
CSC-RG0359
Background
EP1 receptor (or PTGER1) is a receptor or prostaglandin E2 (PGE2). The receptor may play a role in the smooth muscle contractile response to PGE2 in various tissues. EP1 receptor transactivates EGFR thus activating Akt, while activation of EGFR by its cognate ligand EGF increased COX-2 expression and PGE2 production. This crosstalk between EP1 and EGFR signaling synergistically promotes cancer cell growth and invasion. Some EP1-specific antagonists inhibit osteoclast formation induced by RANKL from the early stage of osteoclastogenesis. This cell line expresses EP1 cDNA that is identical to GenBank NM_000955.2 except for 1 sense mutation, Thr→Ala at position 70. It has been reported as a natural variant.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T
Ship
Dry ice
Gene Information
Official Symbol
PTGER1
Synonyms
PTGER1; prostaglandin E receptor 1 (subtype EP1), 42kDa; prostaglandin E receptor 1 (subtype EP1), 42kD; prostaglandin E2 receptor EP1 subtype; EP1; prostanoid EP1 receptor; PGE receptor EP1 subtype; PGE receptor, EP1 subtype; PGE2 receptor EP1 subtype; prostaglandin E receptor 1, subtype EP1;
Gene ID
MIM
UniProt ID
P34995
Chromosome Location
19p13.1
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem;
Function
G-protein coupled receptor activity; prostaglandin E receptor activity; receptor activity; signal transducer activity;
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Cat#
Product Name
Titer
Product Size
Species
Price
AD13134Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human

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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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