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Human PTGER1-FLAG Stable Cell Line-HEK293T

Cat.No.
CSC-RG0359
Abbr
HEK293T-HuPTGER1-FLAG
Alias
PTGER1
Growth Properties
Adherent
Host Cell
HEK293T
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
EP1 receptor (or PTGER1) is a receptor or prostaglandin E2 (PGE2). The receptor may play a role in the smooth muscle contractile response to PGE2 in various tissues. EP1 receptor transactivates EGFR thus activating Akt, while activation of EGFR by its cognate ligand EGF increased COX-2 expression and PGE2 production. This crosstalk between EP1 and EGFR signaling synergistically promotes cancer cell growth and invasion. Some EP1-specific antagonists inhibit osteoclast formation induced by RANKL from the early stage of osteoclastogenesis. This cell line expresses EP1 cDNA that is identical to GenBank NM_000955.2 except for 1 sense mutation, Thr→Ala at position 70. It has been reported as a natural variant.

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