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Human PTGDR2/beta-Arrestin Stable Cell Line-CHO

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Cat.No.
CSC-RG1458
Background
The chemoattractant-homologous receptor expressed on TH2 cells (CRTH2, also known as DP2 and GPR44) serves as a receptor for prostaglandin D2 (PGD2) and has been reported to mediate PGD2-dependent migration of eosinophils. DP2 mediates the pro-inflammatory effects of PGD2 generated in allergic inflammation. 11-Dehydrothromboxane B2 (11-dehydro-TXB2) was found to be a full agonist of the DP2 receptor and hence might cause the receptor activation in cellular contexts where PGD-synthase is not present. Antagonism of the 11-dehydro-TXB2/DP2 axis may be of therapeutic relevance.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
PTGDR2
Synonyms
PTGDR2; prostaglandin D2 receptor 2; G protein coupled receptor 44 , GPR44; CD294; chemoattractant receptor homologous molecule expressed on T helper type 2 cells; CRTH2; DP2; G protein-coupled receptor 44; G-protein coupled receptor 44; putative G-protein coupled receptor 44; chemoattractant receptor-homologous molecule expressed on TH2 cells; DL1R; GPR44;
Gene ID
MIM
UniProt ID
Q9Y5Y4
Chromosome Location
11q12-q13.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Prostanoid ligand receptors, organism-specific biosystem;
Function
G-protein coupled receptor activity; N-formyl peptide receptor activity; prostaglandin D receptor activity; prostaglandin F receptor activity; prostaglandin J receptor activity; receptor activity; signal transducer activity;

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