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Human PTGDR2-FLAG Stable Cell Line-HEK293T

Cat.No.
CSC-RG0465
Abbr
HEK293T-HuPTGDR2-FLAG
Alias
PTGDR2,GPR44,CD294,CRTH2,DP2,DL1R
Growth Properties
Adherent
Host Cell
HEK293T
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
The chemoattractant-homologous receptor expressed on TH2 cells (CRTH2, also known as DP2 and GPR44) serves as a receptor for prostaglandin D2 (PGD2) and has been reported to mediate PGD2-dependent migration of eosinophils. DP2 mediates the pro-inflammatory effects of PGD2 generated in allergic inflammation. 11-Dehydrothromboxane B2 (11-dehydro-TXB2) was found to be a full agonist of the DP2 receptor and hence might cause the receptor activation in cellular contexts where PGD-synthase is not present. Antagonism of the 11-dehydro-TXB2/DP2 axis may be of therapeutic relevance.

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