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Human PTGDR/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0733
Background
Prostanoids are a series of arachidonic acid metabolites produced by the action of cyclooxygenase and subsequently by isomerases and synthases. Cells rapidly secrete prostanoids after synthesis, whereupon the prostanoids bind to a family of 8 GPCRs to exert their biological effects. The prostaglandin PGD2 is produced by mast cells upon activation by allergens, and is present at high levels in allergic diseases. PGD2 binds to two receptors, DP and CRTH2. DP activates Gs to increase cAMP levels, and lack of DP results in reduced allergic response in animal models of bronchial asthma.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
PTGDR
Synonyms
PTGDR; prostaglandin D2 receptor (DP); prostaglandin D2 receptor; DP; DP1; PTGDR1; PGD receptor; PGD2 receptor; AS1; ASRT1; MGC49004;
Gene ID
MIM
UniProt ID
Q13258
Chromosome Location
14q22.1
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Eicosanoid ligand-binding receptors, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; prostaglandin D receptor activity; prostaglandin J receptor activity; protein binding; receptor activity; signal transducer activity;

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