Peroxisome Proliferator-Activated Receptor-gamma (PPAR gamma) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with retinoic acid-like receptor (RXR). It is involved in the regulation of glucose and lipid metabolism. Agonists include the class of anti-diabetic agents called thiazolidinediones (TZD) or "glitazones." Rosiglitazone (Avandia) and Pioglitazone (Actos) are two PPAR gamma agonists currently marketed for treatment of type 2 diabetes. PPAR gamma agonists may also be therapeutically important in the treatment of coronary artery disease, obesity, and cancer.
Adipogenesis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem;
DNA binding; RNA polymerase II regulatory region DNA binding; activating transcription factor binding; arachidonic acid binding; chromatin binding; drug binding; enzyme binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; prostaglandin receptor activity; protein binding; receptor activity; retinoid X receptor binding; contributes_to sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription regulatory region DNA binding; transcription regulatory region DNA binding; zinc ion binding;