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Human PPAR gamma(LBD)-GAL4(DBD) Stable Cell Line-HEK 293T(UAS-bla)

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Cat.No.
CSC-RN0018
Background
Peroxisome Proliferator-Activated Receptor-gamma (PPAR gamma) is a member of the nuclear receptor family of ligand-activated transcription factors that heterodimerize with retinoic acid-like receptor (RXR). It is involved in the regulation of glucose and lipid metabolism. Agonists include the class of anti-diabetic agents called thiazolidinediones (TZD) or "glitazones." Rosiglitazone (Avandia) and Pioglitazone (Actos) are two PPAR gamma agonists currently marketed for treatment of type 2 diabetes. PPAR gamma agonists may also be therapeutically important in the treatment of coronary artery disease, obesity, and cancer.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK 293T
Ship
Dry ice
Gene Information
Official Symbol
PPARG
Synonyms
PPARG; peroxisome proliferator-activated receptor gamma; peroxisome proliferative activated receptor, gamma; NR1C3; PPARG1; PPARG2; PPARgamma; PPAR gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated receptor gamma 1; peroxisome proliferator-activated nuclear receptor gamma variant 1; GLM1; CIMT1;
Gene ID
MIM
UniProt ID
P37231
Chromosome Location
3p25
Pathway
Adipogenesis, organism-specific biosystem; Calcineurin-regulated NFAT-dependent transcription in lymphocytes, organism-specific biosystem; Developmental Biology, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem;
Function
DNA binding; RNA polymerase II regulatory region DNA binding; activating transcription factor binding; arachidonic acid binding; chromatin binding; drug binding; enzyme binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; prostaglandin receptor activity; protein binding; receptor activity; retinoid X receptor binding; contributes_to sequence-specific DNA binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; transcription regulatory region DNA binding; transcription regulatory region DNA binding; zinc ion binding;

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