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Human PPAR delta (LBD)-GAL4 (DBD) Stable Cell Line-HEK 293T(UAS-bla)

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Cat.No.
CSC-RN0016
Background
Peroxisome proliferators-activated receptors (PPARs) are ligand inducible transcription factors of the nuclear receptor superfamily, capable of acting as co-repressors and/or co-activators for gene expression. Nuclear receptors contain a series of conserved domains or regions. These domains/regions include a variable NH2-domain (A/B region), a conserved DNA-binding domain (DBD or region C), a linker region (region D), a ligand binding domain (LBD or region E), and in some receptors a variable COOH-terminal (region F).
Three distinct subtypes of PPARs include PPAR alpha, PPAR delta and PPAR gamma, respectively. All PPAR subfamily members heterodimerize with the receptor for 9-cis retinoic acid (RXR) and bind to target gene peroxisome proliferators elements (PPREs), a direct repeat of the sequence AGGTCA separated by one nucleotide (DR-1). Although the function of PPAR delta, which is expressed ubiquitously, is less well known, this subtype may be involved in the regulation of cholesterol and lipid metabolism, in keratinocyte proliferation and in apoptosis. Among the three PPARs, PPAR delta distinguished itself by displaying remarkably potent transcriptional repression activity. Agonist binding to PPAR delta ligand binding domain provokes a conformational change that produces a suitable binding surface for recruitment of coactivators. These conformational changes lead to a decrease in the affinity of transcription co-repressors and the interaction with transcription co-activators. These co-activators and co-repressors regulate gene transcription by interacting with the transcriptional pre-initiation complex and histone acetyl transferases.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK 293T
Ship
Dry ice
Gene Information
Official Symbol
PPARD
Synonyms
PPARD; peroxisome proliferator-activated receptor delta; peroxisome proliferative activated receptor, delta; FAAR; NR1C2; NUC1; NUCII; PPAR-beta; PPAR-delta; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta; peroxisome proliferator-activated nuclear receptor beta/delta variant 2; NUCI; PPARB; MGC3931;
Gene ID
MIM
UniProt ID
Q03181
Chromosome Location
6p21.2
Pathway
Acute myeloid leukemia, organism-specific biosystem; Acute myeloid leukemia, conserved biosystem; Adipogenesis, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem;
Function
DNA binding; drug binding; fatty acid binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; linoleic acid binding; lipid binding; metal ion binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; zinc ion binding;

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