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Human PPAR alpha (LBD)-GAL4 (DBD) Stable Cell Line-HEK 293T(UAS-bla)

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Cat.No.
CSC-RN0014
Background
The peroxisome proliferator-activated receptors (PPARs) are ligand inducible transcription factors of the nuclear receptor superfamily, capable of acting as co-repressors and/or coactivators for gene expression. Nuclear receptors contain a series of conserved domains or regions. These domains/regions include a variable NH2-domain (A/B region), a conserved DNA-binding domain (DBD or region C), a linker region (region D), a ligand binding domain (LBD or region E), and in some receptors a variable COOH-terminal (region F). Three distinct subtypes of PPARs are known as PPAR alpha, PPAR beta/delta, and PPAR gamma respectively. All of PPAR subfamily members heterodimerize with the receptor for 9-cis retinoic acid (RXR) and bind to target gene peroxisome proliferators elements (PPREs), a direct repeat of the sequence AGGTCA separated by one nucleotide (DR-1). PPAR alpha is expressed mainly in the liver, heart, kidneys, and brain. It plays a role in the uptake and oxidation of fatty acids and lipoprotein metabolism. Activation of PPAR alpha by fibrates lowers triglycerides, raises HDL, and has insulin sensitizing effects. PPAR alpha also regulates neural cell differentiation and has been associated with neurodegeneration and inflammation. Fatty acids, hypolipidemic drugs, and xenobiotics are all ligands of PPAR alpha.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK 293T
Ship
Dry ice
Gene Information
Official Symbol
PPARA
Synonyms
PPARA; peroxisome proliferator-activated receptor alpha; peroxisome proliferative activated receptor, alpha , PPAR; hPPAR; NR1C1; PPAR-alpha; nuclear receptor subfamily 1 group C member 1; peroxisome proliferative activated receptor, alpha; peroxisome proliferator-activated nuclear receptor alpha variant 3; PPAR; PPARalpha; MGC2237; MGC2452;
Gene ID
UniProt ID
Q07869
Chromosome Location
22q12-q13.1
Pathway
Adipocytokine signaling pathway, organism-specific biosystem; Adipocytokine signaling pathway, conserved biosystem; Adipogenesis, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; Circadian Repression of Expression by REV-ERBA, organism-specific biosystem; Developmental Biology, organism-specific biosystem;
Function
DNA binding; MDM2 binding; drug binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; lipid binding; metal ion binding; protein binding; protein domain specific binding; receptor activity; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; ubiquitin conjugating enzyme binding; zinc ion binding;

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