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Human P2RY4/beta-Arrestin Stable Cell Line-HEK293

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Cat.No.
CSC-RG1573
Background
P2Y4 is a 365-amino acid 7 transmembrane protein. It has been shown that, when expressed in a mammalian cell line, the receptor protein was activated specifically by UTP and UDP, but not by ATP and ADP. Activation of P2RY4 resulted in increased inositol phosphate formation and calcium mobilization. Adrian et al, anazlyed the espression of several purinergic receptors during differentiation in a promyelocytic leukemia cell line. Granulocytic differentiation was induced by dimethylsulfoxide, and a monocytic/macrophage phenotype was induced by phorbol esters. P2RY4 was highly expressed in uninduced promyelocytes, and its expression decreased slightly following both granulocytic and monocytic differentiation.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
P2RY4
Synonyms
P2RY4; pyrimidinergic receptor P2Y, G-protein coupled, 4; P2Y purinoceptor 4; NRU; P2P; P2Y4; UNR; uridine nucleotide receptor;
Gene ID
MIM
UniProt ID
P51582
Chromosome Location
Xq13
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
ATP binding; G-protein coupled purinergic nucleotide receptor activity; G-protein coupled receptor activity; UTP-activated nucleotide receptor activity; receptor activity; signal transducer activity; uridine nucleotide receptor activity;

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