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Human P2RY2-FLAG Stable Cell Line-1321N1

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Cat.No.
CSC-RG0378
Background
The P2Y2 receptor was the first of this family of receptors that can be fully activated by both ATP and UTP. P2Y2 receptors are present on all of the body"s mucosal surfaces, including the lungs, eyes, upper airways, mouth, vaginal tract and gastrointestinal tract. P2Y2 receptors have also been found on non-mucosal surfaces, such as the retinal pigment epithelium. Activation of P2Y2 has been shown to stimulate mucosal hydration and mucociliary clearance in the lungs and upper airways and induce secretion of therapeutically significant amounts of fluid and tear components to the ocular surface. Thus, P2Y2 receptors are therapeutic targets for treating serious disorders including cystic fibrosis, a fatal genetic disease, retinal detachment as well as dry eye disease.
Growth Properties
Adherent
Morphology
Glial
Host Cell
1321N1
Ship
Dry ice
Gene Information
Official Symbol
P2RY2
Synonyms
P2RY2; HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R; purinergic receptor P2Y, G-protein coupled, 2; ATP receptor; P2U nucleotide receptor; P2U purinoceptor 1; P2Y purinoceptor 2; purinergic receptor P2Y2; purinoceptor P2Y2
Gene ID
MIM
UniProt ID
P41231
Chromosome Location
11q13.5-q14.1
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (q) signalling events; GPCR downstream signaling; GPCRs, Class A Rhodopsin-like; GPCR ligand binding; Gastrin-CREB signalling pathway via PKC and MAPK; Neuroactive ligand-receptor interaction;
Function
A1 adenosine receptor binding; ATP binding; G-protein coupled purinergic nucleotide receptor activity; receptor activity; UTP-activated nucleotide receptor activity

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