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Human P2RY2/Clytin Stable Cell Line-1321N1

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Cat.No.
CSC-RG0725
Background
The P2Y GPCRs serve as receptors for extracellular nucleotides. P2Y2 (also known as P2U) is activated by UTP and ATP, and couples to Gq to increase intracellular calcium. The P2Y2 receptor knockout mouse displays defective nucleotide-stimulated Cl-secretion, and a P2Y2 selective agonist increases tracheal epithelial chloride and mucin secretion in dog tracheal epithelium and cultured human airway epithelium, respectively. As a result, P2Y2 is a potential target for treatment of cystic fibrosis. In addition, the P2Y2 KO mouse displays salt-resistant hypertension.
Growth Properties
Adherent
Morphology
Glial
Host Cell
1321N1
Ship
Dry ice
Gene Information
Official Symbol
P2RY2
Synonyms
P2RY2; HP2U; P2RU1; P2U; P2U1; P2UR; P2Y2; P2Y2R; purinergic receptor P2Y, G-protein coupled, 2; ATP receptor; P2U nucleotide receptor; P2U purinoceptor 1; P2Y purinoceptor 2; purinergic receptor P2Y2; purinoceptor P2Y2
Gene ID
MIM
UniProt ID
P41231
Chromosome Location
11q13.5-q14.1
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (q) signalling events; GPCR downstream signaling; GPCRs, Class A Rhodopsin-like; GPCR ligand binding; Gastrin-CREB signalling pathway via PKC and MAPK; Neuroactive ligand-receptor interaction;
Function
A1 adenosine receptor binding; ATP binding; G-protein coupled purinergic nucleotide receptor activity; receptor activity; UTP-activated nucleotide receptor activity

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