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Human P2RY14-FLAG Stable Cell Line-HEK293T Galphaqi5

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Cat.No.
CSC-RG0376
Background
P2Y14 (GPR105) is a purinergic G protein-coupled receptor that specifically responds to UDP-glucose and related sugar-nucleotides. This receptor has important structural similarities to known members of the P2Y receptor family but also shows a distinctly different pharmacological profile, as the receptor does not respond to ATP, ADP, UTP, UDP, other nucleotides, dinucleotides, and nucleosides. Widespread distribution of P2Y14 has been observed in humans, with highest expression in placenta, adipose tissue, stomach and intestine, and moderate levels in the brain, spleen, lung and heart. In transfected cells, the P2Y14 receptor reportedly couples to pertussis toxin-sensitive Galphai/o proteins. However, the transduction pathway(s) used by this receptor in native systems still remains to be defined.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293T Galphaqi5
Ship
Dry ice
Gene Information
Official Symbol
P2RY14
Synonyms
P2RY14; GPR105; P2Y14; purinergic receptor P2Y, G-protein coupled, 14; G protein coupled receptor for UDP-glucose; G protein-coupled receptor 105; G-protein coupled receptor 105; P2Y purinoceptor 14; P2Y receptor; P2Y14 receptor; UDP-glucose receptor
Gene ID
MIM
UniProt ID
Q15391
Chromosome Location
3q24-q25.1
Pathway
Class A/1 (Rhodopsin-like receptors); G alpha (i) signalling events; GPCR downstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like; Neuroactive ligand-receptor interaction; Signal Transduction;
Function
G-protein coupled purinergic nucleotide receptor activity; UDP-activated nucleotide receptor activity

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