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Human P2RY14-FLAG Stable Cell Line-HEK293T Galphaqi5

Cat.No.
CSC-RG0376
Abbr
HEK293T Galphaqi5-HuP2RY14-FLAG
Alias
P2RY14,GPR105,P2Y14
Growth Properties
Adherent
Host Cell
HEK293T Galphaqi5
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
P2Y14 (GPR105) is a purinergic G protein-coupled receptor that specifically responds to UDP-glucose and related sugar-nucleotides. This receptor has important structural similarities to known members of the P2Y receptor family but also shows a distinctly different pharmacological profile, as the receptor does not respond to ATP, ADP, UTP, UDP, other nucleotides, dinucleotides, and nucleosides. Widespread distribution of P2Y14 has been observed in humans, with highest expression in placenta, adipose tissue, stomach and intestine, and moderate levels in the brain, spleen, lung and heart. In transfected cells, the P2Y14 receptor reportedly couples to pertussis toxin-sensitive Galphai/o proteins. However, the transduction pathway(s) used by this receptor in native systems still remains to be defined.

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