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Human P2RY12 Stable Cell Line-1321N1 astrocytoma expressing Gqi3

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Cat.No.
CSC-RG0916
Background
The human P2Y12 is an ADP receptor involved in platelet aggregation. ADP initiates platelet aggregation by simultaneous activation of two G protein-coupled receptors, P2Y1 and P2Y12. Activation of P2Y1 stimulates phospholipase C and triggers shape change, while P2Y12 coupled to Gi also involved in modulating thrombosis and hemostasis and therefore is a good drug target for antithrombotic drugs. P2Y receptors are expressed in a variety of tissues including platelets, endothelia, smooth muscle, CNS, osteoblasts , beta-islet cells as well as in commonly used CHO-K1 and HEK293 cells. We therefore chose to express the P2Y12 receptor in 1321N1 astrocytoma cells, which have minimal endogenous receptor.
Growth Properties
Adherent
Morphology
Glial
Host Cell
1321N1 astrocytoma expressing Gqi3
Stability
Stable up to 12 passages of continuous culture (6 weeks)
Ship
Dry ice
Gene Information
Official Symbol
P2RY12
Synonyms
P2RY12; purinergic receptor P2Y, G-protein coupled, 12; P2Y purinoceptor 12; HORK3; P2Y12; SP1999; ADP-glucose receptor; purinergic receptor P2RY12; P2Y12 platelet ADP receptor; Gi-coupled ADP receptor HORK3; G-protein coupled receptor SP1999; putative G-protein coupled receptor; ADPG-R; BDPLT8; P2T(AC); P2Y(AC); P2Y(ADP); P2Y(cyc);
Gene ID
MIM
UniProt ID
Q9H244
Chromosome Location
3q24-q25
Pathway
ADP signalling through P2Y purinoceptor 12, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Hemostasis, organism-specific biosystem;
Function
ADP receptor activity; G-protein coupled adenosine receptor activity; guanyl-nucleotide exchange factor activity; receptor activity; signal transducer activity;

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