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Human OXGR1-FLAG Stable Cell Line-CHO

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Cat.No.
CSC-RG0234
Background
Human GPR99 also known as GPR80 is a G protein-coupled receptor with 337 amino acids. The mRNA of GPR99 was shown to be expressed predominantly in the kidney. Phylogenetic analysis groups GPR99 into the P2Y subfamily of GPCRs. However, deorphanization studies show that it is a close a relative of GPR91 and have proposed the citric acid cycle intermediate alpha-Ketoglutarate as a ligand for GPR99 receptor. The receptor couples to Gq upon ligand binding, promoting intracellular calcium increase and inositol phosphate accumulation.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
OXGR1
Synonyms
OXGR1; GPR80; GPR99; P2RY15; P2Y15; oxoglutarate (alpha-ketoglutarate) receptor 1; 2-oxoglutarate receptor 1; P2Y-like GPCR; P2Y purinoceptor 15; oxoglutarate receptor 1; P2Y-like nucleotide receptor; G protein-coupled receptor 80; G protein-coupled receptor 99; G-protein coupled receptor 80; G-protein coupled receptor 99; alpha-ketoglutarate receptor 1; seven transmembrane helix receptor
Gene ID
MIM
UniProt ID
Q96P68
Chromosome Location
13q32.1
Function
G-protein coupled purinergic nucleotide receptor activity

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