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Human OPRM1 Stable Cell Line-CHO-K1/Gα15

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Cat.No.
CSC-RG1696
Background
This gene encodes one of at least three opioid receptors in humans; the mu opioid receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains.
Host Cell
CHO-K1/Gα15
Ship
Dry Ice
Antigen Gene Information
Official Symbol
OPRM1
Synonyms
OPRM1; opioid receptor, mu 1; mu-type opioid receptor; MOR1; MOP; hMOP; M-OR-1; mu opiate receptor; mu opioid receptor hMOR-1a; mu opioid receptor splice variant hMOR-1S; mu opioid receptor splice variant hMOR-1Z; mu opioid receptor splice variant hMOR-1b; mu opioid receptor splice variant hMOR-1Y2; mu opioid receptor splice variant hMOR-1Y3; MOR; LMOR; OPRM; KIAA0403;
GeneID
MIM
UniProt ID
P35372
Chromosome Location
6q24-q25
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G-protein activation, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; IL4-mediated signaling events, organism-specific biosystem;
Function
G-protein alpha-subunit binding; G-protein coupled receptor activity; beta-endorphin receptor activity; morphine receptor activity; protein binding; receptor activity; signal transducer activity;

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