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Human OPRK1 Stable Cell Line-CHO-K1/Gα15

Cat.No.
CSC-RG1695
Host Cell
CHO-K1/Gα15
Shipping
Dry Ice
Source
CHO-K1/Gα15
Species
Human
Subgroup
Human
Background
The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family ofG-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptordesignated kappa1, kappa2, and kappa3 have been characterized. However only one cDNA clone has beenidentified, hence these receptor subtypes are likely to arise from interaction of one kappa-opioid receptorprotein with other membrane associated proteins. kappa Opioid receptors are located predominantly in thecerebral cortex, nucleus accumbens, claustrum and hypothalamus and have been implicated in the regulation ofnociception, diuresis, feeding and neuroendocrine secretions. Dynorphins A and B and alpha-neoendorphinappear to be the endogenous ligands.
Gene Information
Gene Symbol
OPRK1
Synonyms
KOR; OPRK
Gene Description
opioid receptor, kappa 1
Gene ID
UniProt ID
P41145
mRNA Refseq
Protein Refseq
Chromosome Location
8q11.2
Function
dynorphin receptor activity; protein binding;
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
MIM

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