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Human OPRK1 Stable Cell Line-CHO-K1/Gα15

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Cat.No.
CSC-RG1695
Background
The kappa opioid receptor, (also known as OP2, KOP, KOR), is a member of the opioid family ofG-protein-coupled receptors that also includes mu, delta and NOP receptors. Three variants of the receptordesignated kappa1, kappa2, and kappa3 have been characterized. However only one cDNA clone has beenidentified, hence these receptor subtypes are likely to arise from interaction of one kappa-opioid receptorprotein with other membrane associated proteins. kappa Opioid receptors are located predominantly in thecerebral cortex, nucleus accumbens, claustrum and hypothalamus and have been implicated in the regulation ofnociception, diuresis, feeding and neuroendocrine secretions. Dynorphins A and B and alpha-neoendorphinappear to be the endogenous ligands.
Host Cell
CHO-K1/Gα15
Ship
Dry Ice
Antigen Gene Information
Official Symbol
OPRK1
Synonyms
OPRK1; opioid receptor, kappa 1; kappa-type opioid receptor; KOR; KOR-1; K-OR-1; kappa opioid receptor; Opiate receptor, kappa-1; OPRK;
GeneID
MIM
UniProt ID
P41145
Chromosome Location
8q11.2
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; dynorphin receptor activity; protein binding; receptor activity; signal transducer activity;

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