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Human OPRK1/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0710
Background
Opiates derived from the opium poppy, Papaver somniferum, have been used for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, mu, kappa, and delta, that activate Gi/o to reduce intracellular cAMP levels. Most clinically used opioids function by activation of the mu opioid receptor. Activation of the kappa opioid receptor by selective agonists also produces analgesia, primarily mediated by spinal sites, but causes dysphoria and psychosis instead of euphoria. The kappa receptor at central and peripheral sites is also largely responsible for the anti-diarrheal effects of opiates.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
OPRK1
Synonyms
OPRK1; opioid receptor, kappa 1; kappa-type opioid receptor; KOR; KOR-1; K-OR-1; kappa opioid receptor; Opiate receptor, kappa-1; OPRK;
Gene ID
MIM
UniProt ID
P41145
Chromosome Location
8q11.2
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; dynorphin receptor activity; protein binding; receptor activity; signal transducer activity;
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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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