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Human OPRD1/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0709
Background
Opiates derived from the opium poppy, Papaver somniferum, have been used in for millenia for their anti-diarrheal, analgesic and euphoric properties. More recently, endogenous peptides, enkephalins, dynorphins, and endorphins, were found to bind to the same sites as opiate alkaloids. The receptors for the classical opioids are three related GPCRs, delta, kappa, and mu, also known as OP1, OP2 and OP3, resepctively, that activate Gi/o to reduce intracellular cAMP levels. Although most clinically used opioids function by activation of the mu opioid receptor, agonits of spinal opioid receptors have antinociceptive activity that is independent of mu. In addition, activation of increases locomotor activity, inhibits gastrointestinal motility, and decreases respiratory frequency. Agonists for opioid receptors also exhibit antidepressant-like activity in animal models.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
OPRD1
Synonyms
OPRD1; opioid receptor, delta 1; delta-type opioid receptor; DOR-1; D-OR-1; delta opioid receptor 1; OPRD;
Gene ID
MIM
UniProt ID
P41143
Chromosome Location
1p36.1-p34.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; enkephalin receptor activity; protein binding; receptor activity; signal transducer activity;

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