Creative biogene
SHARE THIS
facebook twitterlinkedingoogle plusStumbleUpon blog


Human O3FAR1-FLAG Stable Cell Line-CHO

See other products for O3FAR1
Cat.No.
CSC-RG0245
Background
GPR120 is a G-protein coupled receptor and has been shown to stimulate secretion of gut hormones GLP-1 and cholecystokinin upon binding of long chain free fatty acids. Stimulation of GPR120 by FFAs results in elevation of Ca2+ and activation of the ERK cascade which suggests interaction with the Gq family of G proteins. GPR120 is expressed in adipose tissue, proinflammatory macrophages and Kupffer cells. Stimulation of GPR120 with agonist causes broad anti-inflammatory effects in macrophages such as insulin sensitizing, antidiabetic effects and macrophage-induced tissue inflammation repression. Recent studies of the -3 FA treatment show inhibited inflammation and enhanced systemic insulin sensitivity in WT mice, but no effect in GPR120 knockout mice. This raises the possibility that targeting this receptor could have therapeutic potential in many inflammatory diseases including obesity and type 2 diabetes.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
O3FAR1
Synonyms
O3FAR1; omega-3 fatty acid receptor 1; G protein coupled receptor 120 , G protein coupled receptor 129 , GPR120, GPR129; PGR4; G protein-coupled receptor 120; G protein-coupled receptor 129; G-protein coupled receptor 120; G-protein coupled receptor 129; G protein-coupled receptor PGR4; G-protein coupled receptor GT01; G-protein coupled receptor PGR4; G-protein-coupled receptor GT01; GT01; BMIQ10; GPR120; GPR129; MGC119984; DKFZp686F0824;
Gene ID
MIM
UniProt ID
Q5NUL3
Chromosome Location
10q23.33
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Free fatty acid receptors, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Incretin Synthesis, Secretion, and Inactivation, organism-specific biosystem; Integration of energy metabolism, organism-specific biosystem; Metabolism, organism-specific biosystem; Regulation of Insulin Secretion, organism-specific biosystem;
Function
fatty acid binding; receptor activity; signal transducer activity; taste receptor activity;
Related Products
Cat#
Product Name
Host Cell
Gene Symbol
Species
Price
CSC-SC010781
HEK293 ,CHO, etc.
O3FAR1
Human
CSC-DC010781
HEK293 ,Hela, etc.
O3FAR1
Human
CSC-RG0067
CHO-K1
O3FAR1
Human
Cat#
Product Name
Titer
Product Size
Species
Price
AD11158Z
>1x 10^9 vp/ml
1 x 0.2 ml
Human

Related Services

Quick Inquiry

Please input "biogene" as verification code.
  Order Info: Human O3FAR1-FLAG Stable Cell Line-CHO  order info
O3FAR1 Related Products
Contact us to order
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828
Email: info@creative-biogene.com
CBpromise

24x7 CUSTOMER SERVICE

CONTACT US TO ORDER

;

CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

Terms & Conditions | Privacy Policy | Sitemap | FAQ | © 2010-2018 Creative Biogene. All Rights Reserved.