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Human NTSR1/beta-Arrestin Stable Cell Line-CHO

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Cat.No.
CSC-RG1561
Background
Neurotensin is a 13 amino acid peptide that induces hypothermia and mediates analgesia when administered centrally, and also mediates the behavioral effects of antipsychotic drugs in rodents. In addition, several intestinal functions, such as contractility and inflammation, are mediated by neurotensin. The actions of neurotensin are mediated by two GPCRs, NTR1 (or NTS1) and NTR2 (or NTS2). NTR1 knockout mice are resistant to the hypothermic, analgesic and contractile effects of neurotensin, indicating that NTR1 is the primary mediator of these effects. Small molecule antagonists, including SR48692 and SR142948A, that are partially selective for NTR1 also interfere with the biological effects of neurotensin.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
NTSR1
Synonyms
NTSR1; neurotensin receptor 1 (high affinity); neurotensin receptor type 1; NTR; NTR1; NTRH; NT-R-1; high-affinity levocabastine-insensitive neurotensin receptor;
Gene ID
MIM
UniProt ID
P30989
Chromosome Location
20q13
Pathway
Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled neurotensin receptor activity; G-protein coupled receptor activity; receptor activity; signal transducer activity;

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