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Human NR3C1 Prom/Luciferase/Hyg Reporter Stable Cell Line-HeLa

See other products for NR3C1
Cat.No.
CSC-RR0028
Background
Glucocorticoids, a major subclass of steroid hormones, modulate a large number of metabolic, cardiovascular, immune, and behavioral functions. The intracellular effects of glucocorticoids are mediated by the glucocorticoid receptor (GR), a 94-kDa intracellular protein belonging to the phylogenetically conserved nuclear hormone receptor superfamily. In the absence of glucocorticoid, the GR is maintained predominantly in the cytoplasm as part of an inactive multiprotein complex that consists of the receptor, two Hsp90 molecules, one molecule each of Hsp70 and Hsp56, and an immunophilin of the FK506- and rapamycin-binding class. When glucocorticoid binds to GR, the receptor undergoes a change in conformation, dissociates from regulatory heat shock proteins, and is hyperphosphorylated. The activated receptor rapidly translocates to the cell nucleus, where it is able to initiate transcriptional regulation.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HeLa
Stability
Cells will undergo genotypic changes resulting in reduced responsiveness over time in normal cell culture conditions. Genetic instability is a biological phenomenon that occurs in all stably transfected cells. Therefore, it is critical to prepare an adequate number of frozen stocks at early passages.
Ship
Dry ice
Gene Information
Official Symbol
NR3C1
Synonyms
NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); GRL, nuclear receptor subfamily 3, group C, member 1; glucocorticoid receptor; GR; glucocorticoid nuclear receptor variant 1; GCR; GRL; GCCR;
Gene ID
UniProt ID
P04150
Chromosome Location
5q31-q32
Pathway
Adipogenesis, organism-specific biosystem; Androgen Receptor Signaling Pathway, organism-specific biosystem; BMAL1:CLOCK/NPAS2 Activates Circadian Expression, organism-specific biosystem; Circadian Clock, organism-specific biosystem; FOXA2 and FOXA3 transcription factor networks, organism-specific biosystem; Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem;
Function
Hsp70 protein binding; Hsp90 protein binding; chromatin binding; double-stranded DNA binding; glucocorticoid receptor activity; metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; receptor activity; receptor tyrosine kinase binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid binding; zinc ion binding;
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