NPY2R (Y2) belongs to the family of G protein-coupled receptors. It is expressed at high levels in central nerve system, heart, ileum and colon. NPY2R shows high affinity for neuropeptide Y (NPY), peptide YY (PYY), and a fragment of NPY including amino acids 13 to 36. The rank order of affinity of this receptor for pancreatic polypeptides is PYY >NPY >PYY (3-36) >NPY (2-36) >[Il-31, Gln-34] PP >[Leu-31, Pro-34] NPY >PP, [Pro-34] PYY and NPY free acid. NPY exhibits a variety of potent central and peripheral effects including those on feeding, memory, blood pressure, and intestinal secretions. NPY2R has been shown to contribute to obesity.