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Human NPY1R/beta-Arrestin Stable Cell Line-CHO

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Cat.No.
CSC-RG1559
Background
NPY1R (Neuropeptide Y receptor type 1) is a receptor for neuropeptide Y that is the most abundant peptide present in the mammalian central and peripheral nervous system. Neuropeptide Y exhibits a variety of potent central and peripheral effects including those on feeding, memory, blood pressure, cardiac contractility and intestinal secretions. Neuropeptide Y effects are mediated by several different receptor subtypes, Y-1, Y-1-like, Y-2, Y-3, Y-4 and Y-5. NPY1R is correlated with food feeding and subnanomolar antagonists of NPY1R have been discovered as potential anti-obesity agents. NPY1R is also involved in cardiovascular actions of exogenous neuropeptide Y and plays a role in maintaining basal blood pressure and heart rate in ischaemic heart failure.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
NPY1R
Synonyms
NPY1R; neuropeptide Y receptor Y1; NPYR; neuropeptide Y receptor type 1; NPY1-R;
Gene ID
MIM
UniProt ID
P25929
Chromosome Location
4q31.3-q32
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; neuropeptide Y receptor activity; pancreatic polypeptide receptor activity; peptide YY receptor activity; receptor activity; signal transducer activity;

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