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Human NPBWR1/Galpha15 Stable Cell Line-Chem-4

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Cat.No.
CSC-RG0702
Background
Neuropeptide B (NPB) and neuropeptide W (NPW) are members of a recently identified neuropeptide family that are ligands for two highly similar receptors, NPBW1 (GPR7) and NPBW2 (GPR8), both of which couple to Gi/o to inhibit intracellular cAMP production. Highest expression of NPBW1 mRNA and protein was identified in the amygdala and hypothalamic nuclei. Physiological studies demonstrate that intracerebroventricular infusion of NPBW1 ligands modulates feeding behaviour, nociception, and release of corticosterone, prolactin and growth hormone. NPBW1 knock out male mice have shown mild adult-onset obesity and decreased locomotor activity. They become progressively hyperglycaemic and hyperinsulinaemic.
Growth Properties
Adherent
Host Cell
Chem-4
Ship
Dry ice
Gene Information
Official Symbol
NPBWR1
Synonyms
NPBWR1; neuropeptides B/W receptor 1; G protein coupled receptor 7 , GPR7; neuropeptides B/W receptor type 1; neuropeptide B/W receptor 1; G protein-coupled receptor 7; G-protein coupled receptor 7; opioid-somatostatin-like receptor 7; GPR7; MGC129755;
Gene ID
MIM
UniProt ID
P48145
Chromosome Location
8p22-q21.13
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; opioid receptor activity; protein binding; receptor activity; signal transducer activity;

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