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Human MTNR1A Stable Cell Line-CHO-K1/Gα15

Cat.No.
CSC-RG1686
Host Cell
CHO-K1/Gα15
Shipping
Dry Ice
Source
CHO-K1/Gα15
Species
Human
Subgroup
Human
Background
This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.
Gene Information
Gene Symbol
MTNR1A
Synonyms
MT1; MEL-1A-R
Gene Description
melatonin receptor 1A
Gene ID
UniProt ID
P48039
mRNA Refseq
Protein Refseq
Chromosome Location
4q35.1
Function
hormone binding; melatonin receptor activity; organic cyclic compound binding;
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
MIM

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