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Human MCHR2/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0695
Background
Melanin-concentrating hormone (MCH) is a cyclic, 19 amino acid peptide produced in the lateral hypothalamus and other regions of the mammalian brain. When administered intracerebrally or overexpressed transgenically in rodents, MCH stimulates food intake and weight gain. Two G protein-coupled receptors for MCH, MCHR1 and MCHR2, have been identified in humans, although rodents appear only to have MCHR1. Both MCHR1 and MCHR2 are expressed primarily in brain. MCHR1 has been demonstrated by genetic and pharmacological methods in rodent models to mediate obesity caused by a high fat diet or leptin deficiency. However, MCHR2 might play a similar role in the species that express it.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
MCHR2
Synonyms
MCHR2; melanin-concentrating hormone receptor 2; G protein coupled receptor 145 , GPR145; MCH2; MCH2R; SLT; MCH receptor 2; G protein-coupled receptor 145; G protein-coupled receptor slt; G-protein coupled receptor 145; melanin-concentrating hormone 2; GPR145; GPRv17; MCH-2R; MCH-R2; MCHR-2;
Gene ID
MIM
UniProt ID
Q969V1
Chromosome Location
6q16
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Other, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; receptor activity; signal transducer activity;

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