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Human MCHR1/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1302
Background
Melanin-concentrating hormone (MCH) is a cyclic, 19 amino acid peptide produced in the lateral hypothalamus and other regions of the mammalian brain. When administered intracerebrally or overexpressed transgenically in rodents, MCH stimulates food intake and weight gain. A receptor for MCH, previously identified as an orphan receptor SLC-1 and renamed MCHR1, has been identified in humans and rodents. Consistent with a role in hypothalmic control of feeding behavior, MCHR1 is expressed in in the ventromedial and dorsomedial nuclei of the hypothalamus. Genetic ablation and pharmacological antagonism of MCHR1 in rodents results in resistance to obesity caused by a high fat diet or leptin deficiency. Thus, MCHR1 is an attractive target for obesity.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
MCHR1
Synonyms
MCHR1; melanin-concentrating hormone receptor 1; G protein coupled receptor 24 , GPR24; MCH1R; SLC1; SLC-1; MCH-1R; MCH receptor 1; G protein-coupled receptor 24; somatostatin receptor-like protein; GPR24; MGC32129;
Gene ID
MIM
UniProt ID
Q99705
Chromosome Location
22q13.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem;
Function
G-protein coupled receptor activity; hormone binding; melanin-concentrating hormone receptor activity; neuropeptide receptor activity; protein C-terminus binding; receptor activity; signal transducer activity;

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