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Human MC4R/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1304
Background
The melanocortins, alpha-, beta- and -melanocyte-stimulating hormones (MSHs), are peptides derived from a precursor protein POMC. The MSH peptides bind to a family of five Gs-coupled seven transmembrane recptors (MC1-5) and play important roles in energy balance, reproductive function, pigmentation and inflammation. The activity of the melanocortins is modulated by endogenous antagonist proteins, agouti and agouti-related protein (AGRP). MC4 is expressed primarily in the CNS and appears to play a prominent role in energy homeostasis. The hypothalamus, which is a major central site for control of feeding behavior, prominently expresses MC4. Targeted deletion of MC4 in mice and naturally occurring mutations in MC4 in humans result in obese phenotypes. In addition, blockade of MC4 function by antagonists and targeted deletion of the gene in mice reverses melanocortin agonist-induced inhibition of food intake and promotes weight gain in uremia and cancer-induced cachexia.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
MC4R
Synonyms
MC4R; melanocortin 4 receptor; melanocortin receptor 4; MC4-R; MGC126851; MGC138197;
Gene ID
MIM
UniProt ID
P32245
Chromosome Location
18q22
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; GPCRs, Class A Rhodopsin-like, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem;
Function
G-protein coupled receptor activity; melanocortin receptor activity; melanocyte-stimulating hormone receptor activity; neuropeptide binding; peptide hormone binding; protein binding; receptor activity; signal transducer activity; ubiquitin protein ligase binding;
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45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

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