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Human MC1R/beta-Arrestin Stable Cell Line-U2OS

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Cat.No.
CSC-RG1543
Background
The melanocortin 1 receptor is one of the key proteins in regulating hair and skin color. A member of the family of G-protein-coupled receptors, it functions at the surface of pigment producing cells (called melanocytes). After activation by MSH, the MC1 receptor is coupled to Gs signal pathway and is involved in many physical and pathological processes including skin pigmentation, autoimmune disease, inflammation and melanoma.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
U2OS
Ship
Dry ice
Gene Information
Official Symbol
MC1R
Synonyms
MC1R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocyte-stimulating hormone receptor; MSH R; MC1-R; melanotropin receptor; CMM5; MSH-R; SHEP2; MGC14337;
Gene ID
MIM
UniProt ID
Q01726
Chromosome Location
16q24.3
Pathway
Chaperonin-mediated protein folding, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; Cooperation of Prefoldin and TriC/CCTin actin and tubulin folding, organism-specific biosystem; Diurnally regulated genes with circadian orthologs, organism-specific biosystem; Formation of tubulin folding intermediates by CCT/TriC, organism-specific biosystem; G alpha (s) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem;
Function
G-protein coupled peptide receptor activity; melanocortin receptor activity; melanocyte-stimulating hormone receptor activity; protein binding; receptor activity; signal transducer activity; ubiquitin protein ligase binding;

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