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Human LXR beta (LBD)-GAL4 (DBD) Stable Cell Line-HEK 293T(UAS-bla)

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Cat.No.
CSC-RN0011
Background
LXR beta (liver X receptor beta) is a nuclear hormone receptor that regulates transcription involved in the metabolism of cholesterol and fatty acids. Activation of LXR beta induces reverse cholesterol transport and increases HDL cholesterol in vivo. It is a validated drug target for cardiovascular disease, and has been implicated in diabetes, inflammation and neurodegenerative disease. LXR beta and LXR alpha have a high degree of homology, but have very different tissue distribution. While LXR alpha is expressed in metabolically active tissue (such as the liver, kidney, intestine, adipose tissue, and macrophages), LXR beta is ubiquitously expressed. Both LXR beta and LXR alpha function by forming heterodimers with RXR and subsequently binding to specific DNA response elements within the regulatory regions of their target genes.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK 293T
Ship
Dry ice
Gene Information
Official Symbol
NR1H2
Synonyms
NR1H2; nuclear receptor subfamily 1, group H, member 2; ubiquitously expressed nuclear receptor , UNR; oxysterols receptor LXR-beta; liver X receptor beta; LXR b; NER; NER I; RIP15; LX receptor beta; nuclear receptor NER; liver X nuclear receptor beta; nuclear orphan receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor; UNR; LXRB; LXR-b; NER-I; FLJ17564;
Gene ID
MIM
UniProt ID
P55055
Chromosome Location
19q13.3
Pathway
Gene Expression, organism-specific biosystem; Generic Transcription Pathway, organism-specific biosystem; Nuclear Receptor transcription pathway, organism-specific biosystem; Nuclear Receptors, organism-specific biosystem;
Function
DNA binding; ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity; metal ion binding; protein binding; receptor activity; retinoid X receptor binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; steroid hormone receptor activity; zinc ion binding;

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