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Human LPAR5/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0685
Background
Lysophosphatidic acid (LPA) is a lysophospholipid produced by activated platelets that inhibits adenylate cyclase and stimulates DNA synthesis, changes in cell morphology, and increases in intracellular calcium in a variety of cultured mammalian cells. A growing family of GPCRs mediates the biological effects of LPA. The first LPA receptors described, LPA1-3, share relatively high sequence similarity and are related to the sphingosine 1-phosphate receptors S1P1-6. Two more recently characterized LPA receptors, LPA4 and LPA6, are related to each other but are more distantly related to LPA1-3. LPA6, originally known as GPR92, mediates LPA-induced cytoskeletal changes, intracellular calcium flux and increased cAMP by coupling to G12/13, Gq, and Gs. In addition to binding LPA, LPA6 is also activated by several other lipid-derived molecules, the most potent of which is farnesyl pyrophosphate. GPR92 is expressed in several tissues, most prominently in the CD8+ intraepithelial lymphocytes of the gastrointestinal tract.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
LPAR5
Synonyms
LPAR5; lysophosphatidic acid receptor 5; G protein coupled receptor 92 , GPR92, GPR93; KPG_010; LPA5; LPA-5; LPA receptor 5; G protein-coupled receptor 92; G-protein coupled receptor 92; G-protein coupled receptor 93; GPR92; GPR93;
Gene ID
MIM
UniProt ID
Q9H1C0
Chromosome Location
12p13.31
Pathway
GPCRs, Class A Rhodopsin-like, organism-specific biosystem;
Function
G-protein coupled purinergic nucleotide receptor activity; G-protein coupled receptor activity; molecular_function; receptor activity; signal transducer activity;

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