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Human LPAR3/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0683
Background
Lysophosphatidic acid (LPA) is a lysophospholipid produced by activated platelets that inhibits adenylate cyclase and stimulates DNA synthesis, changes in cell morphology, and increases in intracellular calcium in a variety of cultured mammalian cells. A family of three GPCRs, LPA1, LPA2 and LPA3, mediates the biological effects of LPA. LPA3 is expressed primarily in testes, prostate, heart and pancreas. Mice lacking LPA3 have low expression of uterine COX-2 and display decreased uterine implantation and embryo spacing.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
LPAR3
Synonyms
LPAR3; lysophosphatidic acid receptor 3; EDG7, endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 7; Edg 7; HOFNH30; LP A3; LPA3; RP4 678I3; LPA-3; LPA receptor 3; LPA receptor EDG7; lysophosphatidic acid receptor Edg-7; endothelial cell differentiation gene 7; calcium-mobilizing lysophosphatidic acid receptor LP-A3; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 7; EDG7; GPCR; Edg-7; LP-A3; RP4-678I3; FLJ98231;
Gene ID
MIM
UniProt ID
Q9UBY5
Chromosome Location
1p22.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; LPA receptor mediated events, organism-specific biosystem; Lysosphingolipid and LPA receptors, organism-specific biosystem;
Function
G-protein alpha-subunit binding; G-protein coupled receptor activity; lipid binding; lysophosphatidic acid receptor activity; phospholipid binding; receptor activity; signal transducer activity;

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