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Human LPAR2/Galpha15 Stable Cell Line-Chem-1

Cat.No.
CSC-RG0684
Abbr
Chem-1-HuLPAR2/Galpha15
Alias
LPAR2,EDG4,EDG 4,LPA2,EDG4,EDG-4,LPA-2,FLJ93869
Growth Properties
Adherent
Host Cell
Chem-1
Shipping
Dry ice
Species
Human
Background
Lysophosphatidic acid (LPA) is a lysophospholipid produced by activated platelets that inhibits adenylate cyclase and stimulates DNA synthesis, changes in cell morphology, and increases in intracellular calcium in a variety of cultured mammalian cells. A family of three GPCRs, LPA1, LPA2 and LPA3, mediates the biological effects of LPA. LPA2 is widely expressed, with particularly notable expression in helper T Cells. LPA2 upregulation has been demonstrated in multiple cancer cells, including colon and ovarian cancer. LPA2 couples to multiple signaling cascades through Gq, Gi/o and G12/13, mediating inhibition of adenyl cyclase, inositol phosphate turnover, calcium flux and cell migration.

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