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Human LPAR2/Galpha15 Stable Cell Line-Chem-1

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Cat.No.
CSC-RG0684
Background
Lysophosphatidic acid (LPA) is a lysophospholipid produced by activated platelets that inhibits adenylate cyclase and stimulates DNA synthesis, changes in cell morphology, and increases in intracellular calcium in a variety of cultured mammalian cells. A family of three GPCRs, LPA1, LPA2 and LPA3, mediates the biological effects of LPA. LPA2 is widely expressed, with particularly notable expression in helper T Cells. LPA2 upregulation has been demonstrated in multiple cancer cells, including colon and ovarian cancer. LPA2 couples to multiple signaling cascades through Gq, Gi/o and G12/13, mediating inhibition of adenyl cyclase, inositol phosphate turnover, calcium flux and cell migration.
Growth Properties
Adherent
Host Cell
Chem-1
Ship
Dry ice
Gene Information
Official Symbol
LPAR2
Synonyms
LPAR2; lysophosphatidic acid receptor 2; EDG4, endothelial differentiation, lysophosphatidic acid G protein coupled receptor, 4; EDG 4; LPA2; LPA receptor 2; LPA receptor EDG4; G protein-coupled receptor; lysophosphatidic acid receptor EDG4; lysophosphatidic acid receptor Edg-4; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4; EDG4; EDG-4; LPA-2; FLJ93869;
Gene ID
MIM
UniProt ID
Q9HBW0
Chromosome Location
19p12
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; LPA receptor mediated events, organism-specific biosystem; Lysosphingolipid and LPA receptors, organism-specific biosystem;
Function
G-protein coupled receptor activity; LIM domain binding; PDZ domain binding; lipid binding; lysophosphatidic acid receptor activity; protein binding; receptor activity; signal transducer activity;

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