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Human LPAR1/Gi Stable Cell Line-CHO

Cat.No.
CSC-RG0555
Abbr
CHO-HuLPAR1/Gi
Alias
LPAR1,EDG2,edg 2,Gpcr26,GPR26,LPA1,Mrec1.3,rec.1.3,vzg 1,LPA-1,EDG2,VZG1,edg-2,vzg-1
Growth Properties
Adherent
Host Cell
CHO-K1
Morphology
Epithelial-like
Shipping
Dry ice
Species
Human
Background
Lysophosphatidic acid (LPA) is a small, bioactive phospholipid that mediates multiple cellular responses, including proliferation, differentiation, motility, and survival in both normal physiology and disease. The extracellular actions of LPA are mediated primarily through its interaction with five G protein-coupled receptors which include LPA1(EDG2), LPA2(EDG4), LPA3(EDG7), LPA4 (GPR23 or P2Y9) and LPA5 (GPR92). Among them, LPA1 (EDG2) is most widely expressed in normal tissue during growth and development. After LPA stimulation, LPA1 (EDG2) couples to Gi and G12/13 and was reported to play an important role in development of chronic neuroimmune disease and initiation of neuropathic pain.

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