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Human KISS1R/beta-Arrestin Stable Cell Line-U2OS

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Cat.No.
CSC-RG1539
Background
GPR54 (also known as AXOR12) is a Gq-coupled GPCR that binds to a series of peptides, termed kisspeptins or metastin, derived from the KiSS-1 gene. The KiSS-1 gene inhibits metastatic activity of melanoma and other tumor cell lines, and clinical evidence supports a role for KiSS-1 and GPR54 in inhibition of metastasis in human cancer. Kisspeptins and GPR54 also play a central role in hypothalamic regulation of puberty, by directly governing the release of gonadotropin-releasing hormone from the hypothalamus. In addition, mutations in GPR54 in mice and humans result in hypogonadotropic hypogonadism.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
U2OS
Ship
Dry ice
Gene Information
Official Symbol
KISS1R
Synonyms
KISS1R; KISS1 receptor; G protein coupled receptor 54 , GPR54; kiSS-1 receptor; AXOR12; HOT7T175; kiSS-1R; metastin receptor; hypogonadotropin-1; kisspeptins receptor; G protein-coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; GPR54;
Gene ID
MIM
UniProt ID
Q969F8
Chromosome Location
19p13.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; Peptide ligand-binding receptors, organism-specific biosystem;
Function
neuropeptide binding; neuropeptide receptor activity; protein binding; receptor activity; signal transducer activity;

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