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Human KISS1R/beta-Arrestin Stable Cell Line-U2OS

Cat.No.
CSC-RG1539
Abbr
U2OS-HuKISS1R/beta-Arrestin
Alias
AXOR12,GPR54,HH8,HOT7T175,KISS-1R
Growth Properties
Adherent
Host Cell
U2OS
Morphology
Epithelial
Shipping
Dry ice
Species
Human
Background
GPR54 (also known as AXOR12) is a Gq-coupled GPCR that binds to a series of peptides, termed kisspeptins or metastin, derived from the KiSS-1 gene. The KiSS-1 gene inhibits metastatic activity of melanoma and other tumor cell lines, and clinical evidence supports a role for KiSS-1 and GPR54 in inhibition of metastasis in human cancer. Kisspeptins and GPR54 also play a central role in hypothalamic regulation of puberty, by directly governing the release of gonadotropin-releasing hormone from the hypothalamus. In addition, mutations in GPR54 in mice and humans result in hypogonadotropic hypogonadism.

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