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Human KISS1R/Apoaequorin Stable Cell Line-CHO

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Cat.No.
CSC-RG1293
Background
GPR54 (also known as AXOR12) is a Gq-coupled GPCR that binds to a series of peptides, termed kisspeptins or metastin, derived from the KiSS-1 gene. The KiSS-1 gene inhibits metastatic activity of melanoma and other tumor cell lines, and clinical evidence supports a role for KiSS-1 and GPR54 in inhibition of metastasis in human cancer. Kisspeptins and GPR54 also play a central role in hypothalamic regulation of puberty, by directly governing the release of gonadotropin-releasing hormone from the hypothalamus. In addition, mutations in GPR54 in mice and humans result in hypogonadotropic hypogonadism.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
KISS1R
Synonyms
KISS1R; KISS1 receptor; G protein coupled receptor 54 , GPR54; kiSS-1 receptor; AXOR12; HOT7T175; kiSS-1R; metastin receptor; hypogonadotropin-1; kisspeptins receptor; G protein-coupled receptor 54; G-protein coupled receptor 54; G-protein coupled receptor OT7T175; GPR54;
Gene ID
MIM
UniProt ID
Q969F8
Chromosome Location
19p13.3
Pathway
Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (q) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem; GPCR ligand binding, organism-specific biosystem; Neuroactive ligand-receptor interaction, organism-specific biosystem; Neuroactive ligand-receptor interaction, conserved biosystem; Peptide ligand-binding receptors, organism-specific biosystem;
Function
neuropeptide binding; neuropeptide receptor activity; protein binding; receptor activity; signal transducer activity;

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