Creative biogene
SHARE THIS
facebook twitterlinkedingoogle plusStumbleUpon blog


Human KCNQ4/KCNQ5 Stable Cell Line-HEK293

See other products for KCNQ4/KCNQ5
Cat.No.
CSC-RI0046
Background
Potassium ion channels are the most widely distributed of ion channels and are found in almost all living organisms. A typical voltage gated potassium ion channel has a tetrameric structure consisting of 4 protein subunits combining to form a central ion conducting pore across the cell membrane. Voltage gated ion channels open and close in response to changes in the transmembrane voltage. KCNQ genes encode Kv7 potassium channels that have been associated with both cardiac and hearing abnormalities in humans, most notably the KNCQ1 gene. Using a partial KCNQ3 cDNA Kubisch et al. screened a human retinal cDNA lambda phage library and obtained a novel homolog they named KCNQ4. When expressed in Xenopus oocytes KCNQ4 encodes potassium current (Kv7.4) inhibited by 30% in the presence of 200 μM linopirdine, whereas the current due to KCNQ3/KCNQ4 (Kv7.3/Kv7.4) heteromers in the same study was inhibited by 75% at that concentration. Schroeder et al. used a KCNQ3 cDNA probe to obtain a KCNQ fragment from a human thalamus cDNA library. Amplification & extension techniques subsequently yielded a full-length KCNQ5 (Kv7.5) gene. These authors also mapped the KCNQ5 gene to the 6q14 region of the human chromosome. Brueggemann et al. found that the inhibition of native potassium currents in A7r5 rat aortic smooth muscle cells by vasopressin was PKC-dependent, and the current amplitude was decreased when RNA interference techniques directed toward KCNQ5 were utilized. Rat middle cerebral arteries have an expression profile of KCNQ4>KCNQ5>KCNQ1 in the sarcolemmal membrane, and linopirdine enhances the myogenic response of the isolated arteries. Agents that open KCNQ channels reverse vasoconstriction, leading to the hypothesis that Kv7 channels could represent novel targets for treatment of cerebral vasospasm.
Growth Properties
Adherent
Morphology
Epithelial
Host Cell
HEK293
Ship
Dry ice
Gene Information
Official Symbol
KCNQ5
Synonyms
KCNQ5; potassium voltage-gated channel, KQT-like subfamily, member 5; potassium voltage-gated channel subfamily KQT member 5; Kv7.5; KQT-like 5; potassium channel protein; potassium channel subunit alpha KvLQT5; voltage-gated potassium channel subunit Kv7.5;
Gene ID
MIM
UniProt ID
Q9NR82
Chromosome Location
6q14
Pathway
Cholinergic synapse, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
Function
inward rectifier potassium channel activity; voltage-gated ion channel activity;
Related Services

Quick Inquiry

Please input "biogene" as verification code.
KCNQ4/KCNQ5 Related Products
Contact us to order
USA
45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828
Email: info@creative-biogene.com
CBpromise

24x7 CUSTOMER SERVICE

CONTACT US TO ORDER

;

CONTACT CREATIVE BIOGENE

45-1 Ramsey Road, Shirley, NY 11967, USA
Tel: 1-631-626-9181
Fax: 1-631-614-7828
Email: info@creative-biogene.com

Europe
Tel: 44-207-097-1828

Terms & Conditions | Privacy Policy | Sitemap | FAQ | © 2010-2018 Creative Biogene. All Rights Reserved.