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Human KCNQ3/KCNQ5 Stable Cell Line-CHO

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Cat.No.
CSC-RI0044
Background
In Mammals, one of the most physiologically-relevant and studied currents is the M current, named this because it is a current observed in neurons in response to addition of muscarine. The M current is inhibited by various brain peptides and M1 muscarinic acetycholine GPCRS. M currents are recorded from brain tissue are all thought to contain Kv7.3, and one combination that appears to be responsible for making M current in neurons in Kv 7.3 with Kv 7.5. These subunits are preferentially expressed in brain & sympathetic ganglia. Openers active on brain currents limit repetitive firing, and their ability to modulate overactivity in dopaminergic & serotonergic pathways is of therapeutic interest for schizophrenia, drug abuse and anxiety.
Growth Properties
Adherent
Morphology
Epithelial-like
Host Cell
CHO-K1
Ship
Dry ice
Gene Information
Official Symbol
KCNQ5
Synonyms
KCNQ5; potassium voltage-gated channel, KQT-like subfamily, member 5; potassium voltage-gated channel subfamily KQT member 5; Kv7.5; KQT-like 5; potassium channel protein; potassium channel subunit alpha KvLQT5; voltage-gated potassium channel subunit Kv7.5;
Gene ID
MIM
UniProt ID
Q9NR82
Chromosome Location
6q14
Pathway
Cholinergic synapse, organism-specific biosystem; Neuronal System, organism-specific biosystem; Potassium Channels, organism-specific biosystem; Voltage gated Potassium channels, organism-specific biosystem;
Function
inward rectifier potassium channel activity; voltage-gated ion channel activity;

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